G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

OBJECTIVE: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...

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Detalles Bibliográficos
Autores principales: Bosma, Karin J., Rahim, Mohsin, Oeser, James K., McGuinness, Owen P., Young, Jamey D., O'Brien, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369601/
https://www.ncbi.nlm.nih.gov/pubmed/32569842
http://dx.doi.org/10.1016/j.molmet.2020.101043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369601/
https://www.ncbi.nlm.nih.gov/pubmed/32569842
http://dx.doi.org/10.1016/j.molmet.2020.101043

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