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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

OBJECTIVE: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...

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Detalles Bibliográficos
Autores principales:	Bosma, Karin J., Rahim, Mohsin, Oeser, James K., McGuinness, Owen P., Young, Jamey D., O'Brien, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369601/ https://www.ncbi.nlm.nih.gov/pubmed/32569842 http://dx.doi.org/10.1016/j.molmet.2020.101043

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