Mitigating local over-fitting during single particle reconstruction with SIDESPLITTER

Single particle analysis has become a key structural biology technique. Experimental images are extremely noisy, and during iterative refinement it is possible to stably incorporate noise into the reconstruction. Such “over-fitting” can lead to misinterpretation of the structure and flawed biologica...

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Detalles Bibliográficos
Autores principales: Ramlaul, Kailash, Palmer, Colin M., Nakane, Takanori, Aylett, Christopher H.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369633/
https://www.ncbi.nlm.nih.gov/pubmed/32534144
http://dx.doi.org/10.1016/j.jsb.2020.107545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369633/
https://www.ncbi.nlm.nih.gov/pubmed/32534144
http://dx.doi.org/10.1016/j.jsb.2020.107545

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