Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

The proteasome is a validated target of cancer therapeutics. Inhibition of proteasome activity results in the activation of the unfolded protein response (UPR) characterized by phosphorylation of eukaryotic initiation factor 2α (eIF2α), global translational arrest, and increased expression of the pr...

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Detalles Bibliográficos
Autores principales: Pellegrini, Paola, Selvaraju, Karthik, Faustini, Elena, Mofers, Arjan, Zhang, Xiaonan, Ternerot, Jens, Schubert, Alice, Linder, Stig, D′Arcy, Pádraig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369842/
https://www.ncbi.nlm.nih.gov/pubmed/32635430
http://dx.doi.org/10.3390/ijms21134757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369842/
https://www.ncbi.nlm.nih.gov/pubmed/32635430
http://dx.doi.org/10.3390/ijms21134757

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