Aspirin Induces Mitochondrial Ca(2+) Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca(2+) Entry

Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca(2+) entry (VGCE) and caspase-3 activation. In the present st...

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Detalles Bibliográficos
Autores principales: Fujikawa, Itsuho, Ando, Takashi, Suzuki-Karasaki, Manami, Suzuki-Karasaki, Miki, Ochiai, Toyoko, Suzuki-Karasaki, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370041/
https://www.ncbi.nlm.nih.gov/pubmed/32635638
http://dx.doi.org/10.3390/ijms21134771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370041/
https://www.ncbi.nlm.nih.gov/pubmed/32635638
http://dx.doi.org/10.3390/ijms21134771

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