Cargando…

Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis

Neutrophils are involved in the alveolitis of idiopathic pulmonary fibrosis (IPF). However, their pathogenic mechanisms are still poorly understood. Nintedanib has antifibrotic and anti-inflammatory activity in IPF. This study aimed to investigate the regulatory mechanism of nintedanib on neutrophil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wei-Chih, Chen, Nien-Jung, Chen, Hsin-Pai, Yu, Wen-Kuang, Su, Vincent Yi-Fong, Chen, Hao, Wu, Huai-Hsuan, Yang, Kuang-Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370174/ https://www.ncbi.nlm.nih.gov/pubmed/32630825 http://dx.doi.org/10.3390/ijms21134735

Ejemplares similares

Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung Injury
por: Su, Vincent Yi-Fong, et al.
Publicado: (2021)

Nintedanib Inhibits Endothelial Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis via Focal Adhesion Kinase Activity Reduction
por: Yu, Wen-Kuang, et al.
Publicado: (2022)

Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis
por: Cheng, I-Yin, et al.
Publicado: (2019)

Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway
por: Zhao, Kaochang, et al.
Publicado: (2023)

NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal Transition via Focal Adhesion Kinase Pathway in Bleomycin-Induced Pulmonary Fibrosis
por: Chen, Wei-Chih, et al.
Publicado: (2023)

The main e-cigarette component vegetable glycerin enhances neutrophil migration and fibrosis in endotoxin-induced lung injury via p38 MAPK activation
por: Su, Vincent Yi-Fong, et al.
Publicado: (2023)

Nintedanib reduces ventilation‐augmented bleomycin‐induced epithelial–mesenchymal transition and lung fibrosis through suppression of the Src pathway
por: Li, Li‐Fu, et al.
Publicado: (2017)

Nintedanib treatment for bleomycin-induced lung injury - First report
por: Rnjak, Dina, et al.
Publicado: (2023)

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol
por: Liu, Meng-Han, et al.
Publicado: (2017)

Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis
por: Hesse, Christina, et al.
Publicado: (2022)

Pulmonary Hypertension Exacerbated by Nintedanib Administration for Idiopathic Pulmonary Fibrosis
por: Shimomura, Iwao, et al.
Publicado: (2018)

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
por: Wollin, Lutz, et al.
Publicado: (2015)

Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis
por: Tomioka, Hiromi, et al.
Publicado: (2017)

Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis
por: Yoon, Hee-Young, et al.
Publicado: (2018)

Clinical use of nintedanib in patients with idiopathic pulmonary fibrosis
por: Hajari Case, Amy, et al.
Publicado: (2017)

Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Tsai, Kuen-Daw, et al.
Publicado: (2011)

Effects of Nintedanib on Quantitative Lung Fibrosis Score in Idiopathic Pulmonary Fibrosis
por: Lancaster, Lisa, et al.
Publicado: (2020)

Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis
por: Cabrini, Giulio, et al.
Publicado: (2020)

Nintedanib Ameliorates Bleomycin-Induced Pulmonary Fibrosis, Inflammation, Apoptosis, and Oxidative Stress by Modulating PI3K/Akt/mTOR Pathway in Mice
por: Pan, Lin, et al.
Publicado: (2023)

Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
por: Choi, Sun Mi, et al.
Publicado: (2016)

Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib
por: Woodcock, Hannah V, et al.
Publicado: (2013)

Immune Mechanisms of Pulmonary Fibrosis with Bleomycin
por: Ishida, Yuko, et al.
Publicado: (2023)

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide
por: Zhang, Xingcai, et al.
Publicado: (2023)

Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
por: Inomata, Minoru, et al.
Publicado: (2015)

Safety, tolerability and appropriate use of nintedanib in idiopathic pulmonary fibrosis
por: Corte, Tamera, et al.
Publicado: (2015)

Efficacy and Safety of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis: An Update
por: Rodríguez-Portal, José Antonio
Publicado: (2017)

Safety of nintedanib added to pirfenidone treatment for idiopathic pulmonary fibrosis
por: Flaherty, Kevin R., et al.
Publicado: (2018)

Effects of nintedanib in patients with idiopathic pulmonary fibrosis by GAP stage
por: Ryerson, Christopher J., et al.
Publicado: (2019)

Colitis Associated with Nintedanib Therapy for Idiopathic Pulmonary Fibrosis (IPF)
por: Oda, Keishi, et al.
Publicado: (2017)

Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume
por: Kolb, Martin, et al.
Publicado: (2017)

Left ventricular dysfunction in an idiopathic pulmonary fibrosis patient on nintedanib
por: Imai, Ryosuke, et al.
Publicado: (2020)

Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis
por: Richeldi, Luca, et al.
Publicado: (2020)

Nintedanib treatment for pulmonary fibrosis after coronavirus disease 2019
por: Ogata, Hiroaki, et al.
Publicado: (2021)

Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing
por: Kato, Kosuke, et al.
Publicado: (2021)

Safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis in Brazil
por: Pereira, Carlos Alberto de Castro, et al.
Publicado: (2019)

Interleukin-22 Inhibits Bleomycin-Induced Pulmonary Fibrosis
por: Liang, Minrui, et al.
Publicado: (2013)

Nintedanib prevented fibrosis progression and lung cancer growth in idiopathic pulmonary fibrosis
por: Fukunaga, Kentaro, et al.
Publicado: (2018)

Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
por: Sato, Seidai, et al.
Publicado: (2017)

Protective Role of Andrographolide in Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Zhu, Tao, et al.
Publicado: (2013)

Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice
por: Liu, Wei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vebtl4n80i10qtp4p7aft311hs