Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms

The aim of this study was to identify novel antimelanogenic drugs from an epigenetic screening library containing various modulators targeting DNA methyltransferases, histone deacetylases, and other related enzymes/proteins. Of 141 drugs tested, K8 (4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-ph...

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Detalles Bibliográficos
Autores principales: Song, Hyerim, Hwang, Yun Jeong, Ha, Jae Won, Boo, Yong Chool
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370187/
https://www.ncbi.nlm.nih.gov/pubmed/32605171
http://dx.doi.org/10.3390/ijms21134589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370187/
https://www.ncbi.nlm.nih.gov/pubmed/32605171
http://dx.doi.org/10.3390/ijms21134589

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