Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

The cellular mechanisms controlling cell fate in self-renewal tissues remain unclear. Cell cycle failure often leads to an apoptosis anti-oncogenic response. We have inactivated Cdk1 or Polo-like-1 kinases, essential targets of the mitotic checkpoints, in the epithelia of skin and oral mucosa. Here,...

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Detalles Bibliográficos
Autores principales: Sanz-Gómez, Natalia, de Pedro, Isabel, Ortigosa, Beatriz, Santamaría, David, Malumbres, Marcos, de Cárcer, Guillermo, Gandarillas, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370216/
https://www.ncbi.nlm.nih.gov/pubmed/32080348
http://dx.doi.org/10.1038/s41418-020-0515-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370216/
https://www.ncbi.nlm.nih.gov/pubmed/32080348
http://dx.doi.org/10.1038/s41418-020-0515-2

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