MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Cells experiencing delays in mitotic progression are prone to undergo apoptosis unless they can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting agents (MTAs) arrest cells in mitosis and induce apoptotic cell death engaging the BCL2 network. Degradation of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Haschka, Manuel D., Karbon, Gerlinde, Soratroi, Claudia, O’Neill, Katelyn L., Luo, Xu, Villunger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370223/
https://www.ncbi.nlm.nih.gov/pubmed/32015503
http://dx.doi.org/10.1038/s41418-020-0503-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370223/
https://www.ncbi.nlm.nih.gov/pubmed/32015503
http://dx.doi.org/10.1038/s41418-020-0503-6

Ejemplares similares