Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle

Mitochondria change distribution across cells following a variety of pathophysiological stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine model overexpressing Drp1 specifically in skeletal muscle, we find marked mitochondria repositioning in muscle fibres and...

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Detalles Bibliográficos
Autores principales: Giovarelli, Matteo, Zecchini, Silvia, Martini, Emanuele, Garrè, Massimiliano, Barozzi, Sara, Ripolone, Michela, Napoli, Laura, Coazzoli, Marco, Vantaggiato, Chiara, Roux-Biejat, Paulina, Cervia, Davide, Moscheni, Claudia, Perrotta, Cristiana, Parazzoli, Dario, Clementi, Emilio, De Palma, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370230/
https://www.ncbi.nlm.nih.gov/pubmed/32042098
http://dx.doi.org/10.1038/s41418-020-0510-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370230/
https://www.ncbi.nlm.nih.gov/pubmed/32042098
http://dx.doi.org/10.1038/s41418-020-0510-7

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