Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

Second generation TRAIL-based therapeutics, combined with sensitising co-treatments, have recently entered clinical trials. However, reliable response predictors for optimal patient selection are not yet available. Here, we demonstrate that a novel and translationally relevant hexavalent TRAIL recep...

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Detalles Bibliográficos
Autores principales: Vetma, Vesna, Guttà, Cristiano, Peters, Nathalie, Praetorius, Christian, Hutt, Meike, Seifert, Oliver, Meier, Friedegund, Kontermann, Roland, Kulms, Dagmar, Rehm, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370234/
https://www.ncbi.nlm.nih.gov/pubmed/32081986
http://dx.doi.org/10.1038/s41418-020-0512-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370234/
https://www.ncbi.nlm.nih.gov/pubmed/32081986
http://dx.doi.org/10.1038/s41418-020-0512-5

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