CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer

BACKGROUND: The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclear in non-small cell lung cancer (NSCLC). METHODS: RNA silencing and pharmacolog...

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Detalles Bibliográficos
Autores principales: Wang, Jian, Zhang, Ruiguang, Lin, Zhenyu, Zhang, Sheng, Chen, Yaobing, Tang, Jing, Hong, Jiaxin, Zhou, Xiaoshu, Zong, Yan, Xu, Yingzhuo, Meng, Rui, Xu, Shuangbing, Liu, Li, Zhang, Tao, Yang, Kunyu, Dong, Xiaorong, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370470/
https://www.ncbi.nlm.nih.gov/pubmed/32690037
http://dx.doi.org/10.1186/s13045-020-00926-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370470/
https://www.ncbi.nlm.nih.gov/pubmed/32690037
http://dx.doi.org/10.1186/s13045-020-00926-x

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