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Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types
Mutational signatures can reveal the history of mutagenic processes that cells were exposed to before and during tumorigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With this in mind, we analyzed the mutational spec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370881/ https://www.ncbi.nlm.nih.gov/pubmed/32661091 http://dx.doi.org/10.1101/gr.255620.119 |
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author | Boot, Arnoud Ng, Alvin W.T. Chong, Fui Teen Ho, Szu-Chi Yu, Willie Tan, Daniel S.W. Iyer, N. Gopalakrishna Rozen, Steven G. |
author_facet | Boot, Arnoud Ng, Alvin W.T. Chong, Fui Teen Ho, Szu-Chi Yu, Willie Tan, Daniel S.W. Iyer, N. Gopalakrishna Rozen, Steven G. |
author_sort | Boot, Arnoud |
collection | PubMed |
description | Mutational signatures can reveal the history of mutagenic processes that cells were exposed to before and during tumorigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With this in mind, we analyzed the mutational spectra of 36 Asian oral squamous cell carcinomas. The mutational spectra of two samples from patients who presented with oral bacterial infections showed novel mutational signatures. One of these novel signatures, SBS_A(n)T, is characterized by a preponderance of thymine mutations, strong transcriptional strand bias, and enrichment for adenines in the 4 bp 5′ of mutation sites. The mutational signature described in this manuscript was shown to be caused by colibactin, a bacterial mutagen produced by E. coli carrying the pks-island. Examination of publicly available sequencing data revealed SBS_A(n)T in 25 tumors from several mucosal tissue types, expanding the list of tissues in which this mutational signature is observed. |
format | Online Article Text |
id | pubmed-7370881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73708812020-12-01 Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types Boot, Arnoud Ng, Alvin W.T. Chong, Fui Teen Ho, Szu-Chi Yu, Willie Tan, Daniel S.W. Iyer, N. Gopalakrishna Rozen, Steven G. Genome Res Research Mutational signatures can reveal the history of mutagenic processes that cells were exposed to before and during tumorigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With this in mind, we analyzed the mutational spectra of 36 Asian oral squamous cell carcinomas. The mutational spectra of two samples from patients who presented with oral bacterial infections showed novel mutational signatures. One of these novel signatures, SBS_A(n)T, is characterized by a preponderance of thymine mutations, strong transcriptional strand bias, and enrichment for adenines in the 4 bp 5′ of mutation sites. The mutational signature described in this manuscript was shown to be caused by colibactin, a bacterial mutagen produced by E. coli carrying the pks-island. Examination of publicly available sequencing data revealed SBS_A(n)T in 25 tumors from several mucosal tissue types, expanding the list of tissues in which this mutational signature is observed. Cold Spring Harbor Laboratory Press 2020-06 /pmc/articles/PMC7370881/ /pubmed/32661091 http://dx.doi.org/10.1101/gr.255620.119 Text en © 2020 Boot et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Boot, Arnoud Ng, Alvin W.T. Chong, Fui Teen Ho, Szu-Chi Yu, Willie Tan, Daniel S.W. Iyer, N. Gopalakrishna Rozen, Steven G. Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title | Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title_full | Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title_fullStr | Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title_full_unstemmed | Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title_short | Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types |
title_sort | characterization of colibactin-associated mutational signature in an asian oral squamous cell carcinoma and in other mucosal tumor types |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370881/ https://www.ncbi.nlm.nih.gov/pubmed/32661091 http://dx.doi.org/10.1101/gr.255620.119 |
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