Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis

OBJECTIVE: To identify transcriptomic changes, neuropathologic correlates, and cellular subpopulations in the motor cortex of sporadic amyotrophic lateral sclerosis (ALS). METHODS: We performed massive RNA sequencing of the motor cortex of patients with ALS (n = 11) and healthy controls (HCs; n = 8)...

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Detalles Bibliográficos
Autores principales: Dols-Icardo, Oriol, Montal, Víctor, Sirisi, Sònia, López-Pernas, Gema, Cervera-Carles, Laura, Querol-Vilaseca, Marta, Muñoz, Laia, Belbin, Olivia, Alcolea, Daniel, Molina-Porcel, Laura, Pegueroles, Jordi, Turón-Sans, Janina, Blesa, Rafael, Lleó, Alberto, Fortea, Juan, Rojas-García, Ricard, Clarimón, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371375/
https://www.ncbi.nlm.nih.gov/pubmed/32669313
http://dx.doi.org/10.1212/NXI.0000000000000829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371375/
https://www.ncbi.nlm.nih.gov/pubmed/32669313
http://dx.doi.org/10.1212/NXI.0000000000000829

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