Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid of both invader and host. This can lead to dormancy...

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Detalles Bibliográficos
Autores principales: Athukoralage, Januka S, McQuarrie, Stuart, Grüschow, Sabine, Graham, Shirley, Gloster, Tracey M, White, Malcolm F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371418/
https://www.ncbi.nlm.nih.gov/pubmed/32597755
http://dx.doi.org/10.7554/eLife.57627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371418/
https://www.ncbi.nlm.nih.gov/pubmed/32597755
http://dx.doi.org/10.7554/eLife.57627

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