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The role of Rif1 in telomere length regulation is separable from its role in origin firing

To examine the established link between DNA replication and telomere length, we tested whether firing of telomeric origins would cause telomere lengthening. We found that RIF1 mutants that block Protein Phosphatase 1 (PP1) binding activated telomeric origins but did not elongate telomeres. In a seco...

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Detalles Bibliográficos
Autores principales: Shubin, Calla B, Greider, Carol W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371424/
https://www.ncbi.nlm.nih.gov/pubmed/32597753
http://dx.doi.org/10.7554/eLife.58066