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The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3

BACKGROUND AND AIM: The pathophysiology of rheumatoid arthritis (RA) is characterized by excess production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) by neutrophils and macrophages in synovium. Additionally, these cytoki...

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Detalles Bibliográficos
Autores principales:	Kanai, Tomotake, Kondo, Naoki, Okada, Masayasu, Sano, Hiroshige, Okumura, Go, Kijima, Yasufumi, Ogose, Akira, Kawashima, Hiroyuki, Endo, Naoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371465/ https://www.ncbi.nlm.nih.gov/pubmed/32131874 http://dx.doi.org/10.1186/s13018-020-01595-9

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