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Detection of COVID-19: A review of the current literature and future perspectives

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accu...

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Autores principales: Ji, Tianxing, Liu, Zhenwei, Wang, GuoQiang, Guo, Xuguang, Akbar khan, Shahzad, Lai, Changchun, Chen, Haoyu, Huang, Shiwen, Xia, Shaomei, Chen, Bo, Jia, Hongyun, Chen, Yangchao, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371595/
https://www.ncbi.nlm.nih.gov/pubmed/32739797
http://dx.doi.org/10.1016/j.bios.2020.112455
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author Ji, Tianxing
Liu, Zhenwei
Wang, GuoQiang
Guo, Xuguang
Akbar khan, Shahzad
Lai, Changchun
Chen, Haoyu
Huang, Shiwen
Xia, Shaomei
Chen, Bo
Jia, Hongyun
Chen, Yangchao
Zhou, Qiang
author_facet Ji, Tianxing
Liu, Zhenwei
Wang, GuoQiang
Guo, Xuguang
Akbar khan, Shahzad
Lai, Changchun
Chen, Haoyu
Huang, Shiwen
Xia, Shaomei
Chen, Bo
Jia, Hongyun
Chen, Yangchao
Zhou, Qiang
author_sort Ji, Tianxing
collection PubMed
description The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic.
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spelling pubmed-73715952020-07-21 Detection of COVID-19: A review of the current literature and future perspectives Ji, Tianxing Liu, Zhenwei Wang, GuoQiang Guo, Xuguang Akbar khan, Shahzad Lai, Changchun Chen, Haoyu Huang, Shiwen Xia, Shaomei Chen, Bo Jia, Hongyun Chen, Yangchao Zhou, Qiang Biosens Bioelectron Article The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic. Published by Elsevier B.V. 2020-10-15 2020-07-21 /pmc/articles/PMC7371595/ /pubmed/32739797 http://dx.doi.org/10.1016/j.bios.2020.112455 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ji, Tianxing
Liu, Zhenwei
Wang, GuoQiang
Guo, Xuguang
Akbar khan, Shahzad
Lai, Changchun
Chen, Haoyu
Huang, Shiwen
Xia, Shaomei
Chen, Bo
Jia, Hongyun
Chen, Yangchao
Zhou, Qiang
Detection of COVID-19: A review of the current literature and future perspectives
title Detection of COVID-19: A review of the current literature and future perspectives
title_full Detection of COVID-19: A review of the current literature and future perspectives
title_fullStr Detection of COVID-19: A review of the current literature and future perspectives
title_full_unstemmed Detection of COVID-19: A review of the current literature and future perspectives
title_short Detection of COVID-19: A review of the current literature and future perspectives
title_sort detection of covid-19: a review of the current literature and future perspectives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371595/
https://www.ncbi.nlm.nih.gov/pubmed/32739797
http://dx.doi.org/10.1016/j.bios.2020.112455
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