Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction

T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and inflammation. Here, we show that effector T cells...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Gnanaprakasam, J. N. Rashida, Chen, Xuyong, Kang, Siwen, Xu, Xuequn, Sun, Hua, Liu, Lingling, Rodgers, Hayley, Miller, Ethan, Cassel, Teresa A., Sun, Qiushi, Vicente-Muñoz, Sara, Warmoes, Marc O., Lin, Penghui, Piedra-Quintero, Zayda Lizbeth, Guerau-de-Arellano, Mireia, Cassady, Kevin A., Zheng, Song Guo, Yang, Jun, Lane, Andrew N., Song, Xiaotong, Fan, Teresa W.-M., Wang, Ruoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371628/
https://www.ncbi.nlm.nih.gov/pubmed/32694789
http://dx.doi.org/10.1038/s42255-020-0219-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371628/
https://www.ncbi.nlm.nih.gov/pubmed/32694789
http://dx.doi.org/10.1038/s42255-020-0219-4

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