N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

N-myristoyltransferase-1 (NMT1) catalyzes protein myristoylation, a lipid modification that is elevated in cancer cells. NMT1 sustains proliferation and/or survival of cancer cells through mechanisms that are not completely understood. We used genetic and pharmacological inhibition of NMT1 to furthe...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yu-Chuan, Navarrete, Marian S., Wang, Ying, McClintock, Natalie C., Sakurai, Reiko, Wang, Feng, Chen, Kathryn T., Chou, Tsui-Fen, Rehan, Virender K., Lee, Delphine J., Diaz, Begoña
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371688/
https://www.ncbi.nlm.nih.gov/pubmed/32686708
http://dx.doi.org/10.1038/s41598-020-68615-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371688/
https://www.ncbi.nlm.nih.gov/pubmed/32686708
http://dx.doi.org/10.1038/s41598-020-68615-w

Ejemplares similares