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N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

N-myristoyltransferase-1 (NMT1) catalyzes protein myristoylation, a lipid modification that is elevated in cancer cells. NMT1 sustains proliferation and/or survival of cancer cells through mechanisms that are not completely understood. We used genetic and pharmacological inhibition of NMT1 to furthe...

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Detalles Bibliográficos
Autores principales:	Chen, Yu-Chuan, Navarrete, Marian S., Wang, Ying, McClintock, Natalie C., Sakurai, Reiko, Wang, Feng, Chen, Kathryn T., Chou, Tsui-Fen, Rehan, Virender K., Lee, Delphine J., Diaz, Begoña
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371688/ https://www.ncbi.nlm.nih.gov/pubmed/32686708 http://dx.doi.org/10.1038/s41598-020-68615-w

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