Cargando…
MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse
Maf1(−/−) mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for nucleotides stemming from the deregulation of RNA polymerase (pol) III transcription....
Autores principales: | Bonhoure, Nicolas, Praz, Viviane, Moir, Robyn D., Willemin, Gilles, Mange, François, Moret, Catherine, Willis, Ian M., Hernandez, Nouria |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371695/ https://www.ncbi.nlm.nih.gov/pubmed/32686713 http://dx.doi.org/10.1038/s41598-020-68665-0 |
Ejemplares similares
-
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance
por: Bonhoure, Nicolas, et al.
Publicado: (2015) -
Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding–fasting response and the circadian clock
por: Mange, François, et al.
Publicado: (2017) -
Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest
por: Orioli, Andrea, et al.
Publicado: (2016) -
Structural basis for RNA polymerase III transcription repression by Maf1
por: Vorländer, Matthias K., et al.
Publicado: (2020) -
MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass
por: Phillips, Ellen, et al.
Publicado: (2022)