Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors

Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-es...

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Detalles Bibliográficos
Autores principales: Kim, Ha-Neui, Ponte, Filipa, Nookaew, Intawat, Ucer Ozgurel, Serra, Marques-Carvalho, Adriana, Iyer, Srividhya, Warren, Aaron, Aykin-Burns, Nukhet, Krager, Kimberly, Sardao, Vilma A., Han, Li, de Cabo, Rafael, Zhao, Haibo, Jilka, Robert L., Manolagas, Stavros C., Almeida, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371870/
https://www.ncbi.nlm.nih.gov/pubmed/32686739
http://dx.doi.org/10.1038/s41598-020-68890-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371870/
https://www.ncbi.nlm.nih.gov/pubmed/32686739
http://dx.doi.org/10.1038/s41598-020-68890-7

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