Defining relative mutational difficulty to understand cancer formation

Most mutations in human cancer are low-frequency missense mutations, whose functional status remains hard to predict. Here, we show that depending on the type of nucleotide change and the surrounding sequences, the tendency to generate each type of nucleotide mutations varies greatly, even by severa...

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Detalles Bibliográficos
Autores principales: Shan, Lin, Yu, Jiao, He, Zhengjin, Chen, Shishuang, Liu, Mingxian, Ding, Hongyu, Xu, Liang, Zhao, Jie, Yang, Ailing, Jiang, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371891/
https://www.ncbi.nlm.nih.gov/pubmed/32704382
http://dx.doi.org/10.1038/s41421-020-0177-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371891/
https://www.ncbi.nlm.nih.gov/pubmed/32704382
http://dx.doi.org/10.1038/s41421-020-0177-8

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