Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

Certain HLA class II genes increase the risk for type 1 diabetes (T1D) development while others provide protection from disease development. HLA class II alleles encode MHC proteins on antigen-presenting cells, which function to present peptides and activate CD4 T cells. The DRB1*15:01 (DR15)-DQA1*0...

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Detalles Bibliográficos
Autores principales: Simmons, Kimber M., Mitchell, Angela M., Alkanani, Aimon A., McDaniel, Kristen A., Baschal, Erin E., Armstrong, Taylor, Pyle, Laura, Yu, Liping, Michels, Aaron W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372070/
https://www.ncbi.nlm.nih.gov/pubmed/32439825
http://dx.doi.org/10.2337/db20-0038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372070/
https://www.ncbi.nlm.nih.gov/pubmed/32439825
http://dx.doi.org/10.2337/db20-0038

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