Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase

[Image: see text] The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone N-methylati...

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Detalles Bibliográficos
Autores principales: Song, Haigang, Fahrig-Kamarauskaitè, Ju̅ratè, Matabaro, Emmanuel, Kaspar, Hannelore, Shirran, Sally L., Zach, Christina, Pace, Amy, Stefanov, Bozhidar-Adrian, Naismith, James H., Künzler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372559/
https://www.ncbi.nlm.nih.gov/pubmed/32491837
http://dx.doi.org/10.1021/acschembio.0c00237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372559/
https://www.ncbi.nlm.nih.gov/pubmed/32491837
http://dx.doi.org/10.1021/acschembio.0c00237

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