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Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase
[Image: see text] The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone N-methylati...
Autores principales: | Song, Haigang, Fahrig-Kamarauskaitè, Ju̅ratè, Matabaro, Emmanuel, Kaspar, Hannelore, Shirran, Sally L., Zach, Christina, Pace, Amy, Stefanov, Bozhidar-Adrian, Naismith, James H., Künzler, Markus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372559/ https://www.ncbi.nlm.nih.gov/pubmed/32491837 http://dx.doi.org/10.1021/acschembio.0c00237 |
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