Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells

Proinflammatory cytokines stimulate expression of β-secretase, which increases processing of amyloid precursor protein (APP), ultimately leading to the deposition of amyloid beta (Aβ). The N-terminal domain of β-cleaved APP supports Cu/NO-dependent release of heparan sulfate (HS) from the glypican-1...

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Detalles Bibliográficos
Autores principales: Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372925/
https://www.ncbi.nlm.nih.gov/pubmed/32039447
http://dx.doi.org/10.1093/glycob/cwaa011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372925/
https://www.ncbi.nlm.nih.gov/pubmed/32039447
http://dx.doi.org/10.1093/glycob/cwaa011

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