Quantifying the nativeness of antibody sequences using long short-term memory networks

Antibodies often undergo substantial engineering en route to the generation of a therapeutic candidate with good developability properties. Characterization of antibody libraries has shown that retaining native-like sequence improves the overall quality of the library. Motivated by recent advances i...

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Detalles Bibliográficos
Autores principales: Wollacott, Andrew M, Xue, Chonghua, Qin, Qiuyuan, Hua, June, Bohnuud, Tanggis, Viswanathan, Karthik, Kolachalama, Vijaya B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372931/
https://www.ncbi.nlm.nih.gov/pubmed/31504835
http://dx.doi.org/10.1093/protein/gzz031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372931/
https://www.ncbi.nlm.nih.gov/pubmed/31504835
http://dx.doi.org/10.1093/protein/gzz031

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