Cargando…

Quantifying the nativeness of antibody sequences using long short-term memory networks

Antibodies often undergo substantial engineering en route to the generation of a therapeutic candidate with good developability properties. Characterization of antibody libraries has shown that retaining native-like sequence improves the overall quality of the library. Motivated by recent advances i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wollacott, Andrew M, Xue, Chonghua, Qin, Qiuyuan, Hua, June, Bohnuud, Tanggis, Viswanathan, Karthik, Kolachalama, Vijaya B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372931/ https://www.ncbi.nlm.nih.gov/pubmed/31504835 http://dx.doi.org/10.1093/protein/gzz031

Ejemplares similares

Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces
por: Bohnuud, Tanggis, et al.
Publicado: (2014)

Interpretable Machine Learning on Metabolomics Data Reveals Biomarkers for Parkinson’s Disease
por: Zhang, J. Diana, et al.
Publicado: (2023)

Detection of dementia on voice recordings using deep learning: a Framingham Heart Study
por: Xue, Chonghua, et al.
Publicado: (2021)

Fusion of Low-Level Descriptors of Digital Voice Recordings for Dementia Assessment
por: Karjadi, Cody, et al.
Publicado: (2023)

ClusPro PeptiDock: efficient global docking of peptide recognition motifs using FFT
por: Porter, Kathryn A, et al.
Publicado: (2017)

A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing
por: Liu, Xin, et al.
Publicado: (2021)

FTMAP: extended protein mapping with user-selected probe molecules
por: Ngan, Chi Ho, et al.
Publicado: (2012)

Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer's disease status
por: Joshi, Prajakta S., et al.
Publicado: (2019)

Enhancing magnetic resonance imaging-driven Alzheimer’s disease classification performance using generative adversarial learning
por: Zhou, Xiao, et al.
Publicado: (2021)

Machine learning and pre-medical education
por: Kolachalama, Vijaya B.
Publicado: (2022)

Computational mapping reveals dramatic effect of Hoogsteen breathing on duplex DNA reactivity with formaldehyde
por: Bohnuud, Tanggis, et al.
Publicado: (2012)

Extending human IgG half-life using structure-guided design
por: Booth, Brian J., et al.
Publicado: (2018)

Auditory Short-Term Memory Behaves Like Visual Short-Term Memory
por: Visscher, Kristina M, et al.
Publicado: (2007)

Modulations of ongoing alpha oscillations predict successful short-term visual memory encoding
por: Nenert, Rodolphe, et al.
Publicado: (2012)

Quantifying the influence of short-term emission reductions on climate
por: Fyfe, J. C., et al.
Publicado: (2021)

Machine learning and medical education
por: Kolachalama, Vijaya B., et al.
Publicado: (2018)

Short-Term Memory and Long-Term Memory are Still Different
por: Norris, Dennis
Publicado: (2017)

Long Term Memory for Noise: Evidence of Robust Encoding of Very Short Temporal Acoustic Patterns
por: Viswanathan, Jayalakshmi, et al.
Publicado: (2016)

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks
por: Wollacott, Andrew M., et al.
Publicado: (2016)

Fusion of deep learning models of MRI scans, Mini–Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment
por: Qiu, Shangran, et al.
Publicado: (2018)

Can short-term memory be trained?
por: Norris, Dennis G., et al.
Publicado: (2019)

Importance of quantifying migraine disability in the native language of the migraineur
por: Gantenbein, Andreas R., et al.
Publicado: (2020)

About the Distinction between Working Memory and Short-Term Memory
por: Aben, Bart, et al.
Publicado: (2012)

Short-term memory as a working memory control process
por: Davelaar, Eddy J.
Publicado: (2013)

Redefining and Validating Digital Biomarkers as Fluid, Dynamic Multi-Dimensional Digital Signal Patterns
por: Au, Rhoda, et al.
Publicado: (2022)

Anti-Ri antibodies associated with short-term memory deficits and a mature cystic teratoma of the ovary
por: Fadare, Oluwole, et al.
Publicado: (2004)

Are There Multiple Visual Short-Term Memory Stores?
por: Sligte, Ilja G., et al.
Publicado: (2008)

Conceptual Short Term Memory in Perception and Thought
por: Potter, Mary C.
Publicado: (2012)

Trisecting representational states in short-term memory
por: Nee, Derek Evan, et al.
Publicado: (2013)

The Effect of Consistency on Short-Term Memory for Scenes
por: Gong, Mingliang, et al.
Publicado: (2017)

Evolving Long Short-Term Memory Networks
por: Lobo Neto, Vicente Coelho, et al.
Publicado: (2020)

Chunking and Redintegration in Verbal Short-Term Memory
por: Norris, Dennis, et al.
Publicado: (2019)

Short-term memory of temporal information revisited
por: Bratzke, Daniel, et al.
Publicado: (2020)

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: A new approach to prevent and treat bacterial infections
por: Johnson, Kenneth, et al.
Publicado: (2023)

NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression
por: Williams Avram, Sarah K., et al.
Publicado: (2019)

Quantifying the Short-Term Costs of Conservation Interventions for Fishers at Lake Alaotra, Madagascar
por: Wallace, Andrea P. C., et al.
Publicado: (2015)

Mining data from hemodynamic simulations via Bayesian emulation
por: Kolachalama, Vijaya B, et al.
Publicado: (2007)

Luminal Flow Amplifies Stent-Based Drug Deposition in Arterial Bifurcations
por: Kolachalama, Vijaya B., et al.
Publicado: (2009)

Machine Learning in Clinical Trials: A Primer with Applications to Neurology
por: Miller, Matthew I., et al.
Publicado: (2023)

Visual short-term memory capacity predicts the “bandwidth” of visual long-term memory encoding
por: Fukuda, Keisuke, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hklts5dja31l0nm6e4r406ltba