Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

In vitro antibody selection against pathogens from naïve combinatorial libraries can yield various classes of antigen-specific binders that are distinct from those evolved from natural infection(1–4). Also, rapid neutralizing antibody discovery can be made possible by a strategy that selects for tho...

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Detalles Bibliográficos
Autores principales: Wang, Bei, Asarnow, Daniel, Lee, Wen-Hsin, Huang, Ching-Wen, Faust, Bryan, Ng, Patricia Miang Lon, Ngoh, Eve Zi Xian, Bohn, Markus, Bulkley, David, Pizzorno, Andrés, Tan, Hwee Ching, Lee, Chia Yin, Minhat, Rabiatul Adawiyah, Terrier, Olivier, Soh, Mun Kuen, Teo, Frannie Jiuyi, Yeap, Yvonne Yee Chin, Hu, Yuanyu, Seah, Shirley Gek Kheng, Maurer-Stroh, Sebastian, Renia, Laurent, Hanson, Brendon John, Rosa-Calatrava, Manuel, Manglik, Aashish, Cheng, Yifan, Craik, Charles S., Wang, Cheng-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373131/
https://www.ncbi.nlm.nih.gov/pubmed/32699850
http://dx.doi.org/10.1101/2020.07.14.203414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373131/
https://www.ncbi.nlm.nih.gov/pubmed/32699850
http://dx.doi.org/10.1101/2020.07.14.203414

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