Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5α2) as a critical integral membrane enzyme in steroid metabolism catalyzes testosterone to dihydrotestosterone. Mutations on its gene have been linked to 5α-reductase deficiency and prostate cancer. Finasteride and dutasteride as SRD5α2 inhibitors are widely used an...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Qingpin, Wang, Lei, Supekar, Shreyas, Shen, Tao, Liu, Heng, Ye, Fei, Huang, Junzhou, Fan, Hao, Wei, Zhiyi, Zhang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373137/
https://www.ncbi.nlm.nih.gov/pubmed/32702725
http://dx.doi.org/10.21203/rs.3.rs-40159/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373137/
https://www.ncbi.nlm.nih.gov/pubmed/32702725
http://dx.doi.org/10.21203/rs.3.rs-40159/v1

Ejemplares similares