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Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5α2) as a critical integral membrane enzyme in steroid metabolism catalyzes testosterone to dihydrotestosterone. Mutations on its gene have been linked to 5α-reductase deficiency and prostate cancer. Finasteride and dutasteride as SRD5α2 inhibitors are widely used an...

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Detalles Bibliográficos
Autores principales:	Xiao, Qingpin, Wang, Lei, Supekar, Shreyas, Shen, Tao, Liu, Heng, Ye, Fei, Huang, Junzhou, Fan, Hao, Wei, Zhiyi, Zhang, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373137/ https://www.ncbi.nlm.nih.gov/pubmed/32702725 http://dx.doi.org/10.21203/rs.3.rs-40159/v1

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