Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models

Parameter estimation of a nonlinear model based on maximizing the likelihood using gradient-based numerical optimization methods can often fail due to premature termination of the optimization algorithm. One reason for such failure is that these numerical optimization methods cannot distinguish betw...

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Detalles Bibliográficos
Autores principales: Bjugård Nyberg, Henrik, Hooker, Andrew C., Bauer, Robert J., Aoki, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373158/
https://www.ncbi.nlm.nih.gov/pubmed/32617704
http://dx.doi.org/10.1208/s12248-020-00471-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373158/
https://www.ncbi.nlm.nih.gov/pubmed/32617704
http://dx.doi.org/10.1208/s12248-020-00471-y

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