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Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models
Parameter estimation of a nonlinear model based on maximizing the likelihood using gradient-based numerical optimization methods can often fail due to premature termination of the optimization algorithm. One reason for such failure is that these numerical optimization methods cannot distinguish betw...
Autores principales: | Bjugård Nyberg, Henrik, Hooker, Andrew C., Bauer, Robert J., Aoki, Yasunori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373158/ https://www.ncbi.nlm.nih.gov/pubmed/32617704 http://dx.doi.org/10.1208/s12248-020-00471-y |
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