Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In...

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Detalles Bibliográficos
Autores principales: Silva, Rafael C. M. C., Travassos, Leonardo H., Paiva, Claudia N., Bozza, Marcelo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373268/
https://www.ncbi.nlm.nih.gov/pubmed/32692767
http://dx.doi.org/10.1371/journal.ppat.1008599
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author Silva, Rafael C. M. C.
Travassos, Leonardo H.
Paiva, Claudia N.
Bozza, Marcelo T.
author_facet Silva, Rafael C. M. C.
Travassos, Leonardo H.
Paiva, Claudia N.
Bozza, Marcelo T.
author_sort Silva, Rafael C. M. C.
collection PubMed
description Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.
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spelling pubmed-73732682020-07-29 Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance Silva, Rafael C. M. C. Travassos, Leonardo H. Paiva, Claudia N. Bozza, Marcelo T. PLoS Pathog Review Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development. Public Library of Science 2020-07-21 /pmc/articles/PMC7373268/ /pubmed/32692767 http://dx.doi.org/10.1371/journal.ppat.1008599 Text en © 2020 Silva et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Silva, Rafael C. M. C.
Travassos, Leonardo H.
Paiva, Claudia N.
Bozza, Marcelo T.
Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title_full Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title_fullStr Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title_full_unstemmed Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title_short Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
title_sort heme oxygenase-1 in protozoan infections: a tale of resistance and disease tolerance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373268/
https://www.ncbi.nlm.nih.gov/pubmed/32692767
http://dx.doi.org/10.1371/journal.ppat.1008599
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