A genetic model of ivabradine recapitulates results from randomized clinical trials

BACKGROUND: Naturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure despite increasing the risk of atrial fibrillation. In pa...

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Detalles Bibliográficos
Autores principales: Legault, Marc-André, Sandoval, Johanna, Provost, Sylvie, Barhdadi, Amina, Lemieux Perreault, Louis-Philippe, Shah, Sonia, Lumbers, R. Thomas, de Denus, Simon, Tyl, Benoit, Tardif, Jean-Claude, Dubé, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373274/
https://www.ncbi.nlm.nih.gov/pubmed/32692755
http://dx.doi.org/10.1371/journal.pone.0236193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373274/
https://www.ncbi.nlm.nih.gov/pubmed/32692755
http://dx.doi.org/10.1371/journal.pone.0236193

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