Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state

Kindlin-1, -2, and -3 directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their functional significance and links to several diseases, structural information on full-length kindlin proteins remains unknown. Here, we report the crystal structure of human...

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Detalles Bibliográficos
Autores principales: Bu, Wenting, Levitskaya, Zarina, Loh, Zhi Yang, Jin, Shengyang, Basu, Shibom, Ero, Rya, Yan, Xinfu, Wang, Meitian, Ngan, So Fong Cam, Sze, Siu Kwan, Tan, Suet-Mien, Gao, Yong-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373317/
https://www.ncbi.nlm.nih.gov/pubmed/32644996
http://dx.doi.org/10.1371/journal.pbio.3000755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373317/
https://www.ncbi.nlm.nih.gov/pubmed/32644996
http://dx.doi.org/10.1371/journal.pbio.3000755

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