Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iro...

Descripción completa

Detalles Bibliográficos
Autores principales: Jenkins, Nicole L, James, Simon A, Salim, Agus, Sumardy, Fransisca, Speed, Terence P, Conrad, Marcus, Richardson, Des R, Bush, Ashley I, McColl, Gawain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373428/
https://www.ncbi.nlm.nih.gov/pubmed/32690135
http://dx.doi.org/10.7554/eLife.56580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373428/
https://www.ncbi.nlm.nih.gov/pubmed/32690135
http://dx.doi.org/10.7554/eLife.56580

Ejemplares similares