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Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization

AIMS: Remimazolam is a new, ultra‐short‐acting benzodiazepine developed for intravenous (IV) use during procedural sedation and in general anaesthesia. Two trials were conducted to characterize its effects on cardiac repolarization. METHODS: A thorough QT/QTc (TQT) study assessed electrocardiography...

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Detalles Bibliográficos
Autores principales: Kleiman, Robert B., Darpo, Borje, Thorn, Michael, Stoehr, Thomas, Schippers, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373701/
https://www.ncbi.nlm.nih.gov/pubmed/32144789
http://dx.doi.org/10.1111/bcp.14270