Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug–drug interactions with different perpetrator drugs

AIMS: Using 3 different perpetrators the impact of voriconazole, cobicistat and rifampicin (single dose), we evaluated the suitability of a microdose cocktail of factor Xa inhibitors (FXaI; rivaroxaban, apixaban and edoxaban; 100 μg in total) to study drug–drug interactions. METHODS: Three cohorts o...

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Detalles Bibliográficos
Autores principales: Mikus, Gerd, Foerster, Kathrin I., Schaumaeker, Marlene, Lehmann, Marie‐Louise, Burhenne, Jürgen, Haefeli, Walter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373712/
https://www.ncbi.nlm.nih.gov/pubmed/32159869
http://dx.doi.org/10.1111/bcp.14277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373712/
https://www.ncbi.nlm.nih.gov/pubmed/32159869
http://dx.doi.org/10.1111/bcp.14277

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