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Enhanced AmB Production in Streptomyces nodosus by Fermentation Regulation and Rational Combined Feeding Strategy

Amphotericin B is a clinically important polyene macrolide antibiotic with a broad-spectrum antifungal activity. In this work, the addition of key precursors and differential metabolites, combined with staged fermentation process control strategies, was carried out to improve AmB production. Rationa...

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Detalles Bibliográficos
Autores principales:	Zhang, Bo, Zhang, Yu-Han, Chen, Yu, Chen, Kai, Jiang, Sheng-Xian, Huang, Kai, Liu, Zhi-Qiang, Zheng, Yu-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373727/ https://www.ncbi.nlm.nih.gov/pubmed/32760700 http://dx.doi.org/10.3389/fbioe.2020.00597

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