Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...

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Detalles Bibliográficos
Autores principales: Machado, Thiago S., Macabelli, Carolina H., Collado, Maite Del, Meirelles, Flávio V., Guimarães, Francisco E. G., Chiaratti, Marcos R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373801/
https://www.ncbi.nlm.nih.gov/pubmed/32760430
http://dx.doi.org/10.3389/fgene.2020.00762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373801/
https://www.ncbi.nlm.nih.gov/pubmed/32760430
http://dx.doi.org/10.3389/fgene.2020.00762

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