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Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse
There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373801/ https://www.ncbi.nlm.nih.gov/pubmed/32760430 http://dx.doi.org/10.3389/fgene.2020.00762 |