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Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer

PURPOSE: Currently, the DNA damage response (DDR) pathway represents a key target for new cancer drug development. Advanced biliary tract cancer (BTC) has a poor prognosis because of the lack of efficacious treatment options. Although DNA repair pathway alterations have been reported in many patient...

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Detalles Bibliográficos
Autores principales: Nam, Ah-Rong, Jin, Mei-Hua, Bang, Ju-Hee, Oh, Kyoung-Seok, Seo, Hye-Rim, Oh, Do-Youn, Bang, Yung-Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373879/
https://www.ncbi.nlm.nih.gov/pubmed/32311864
http://dx.doi.org/10.4143/crt.2020.080