Unmasking features of the auto‐epitope essential for β(1)‐adrenoceptor activation by autoantibodies in chronic heart failure

AIMS: Chronic heart failure (CHF) can be caused by autoantibodies stimulating the heart via binding to first and/or second extracellular loops of cardiac β(1)‐adrenoceptors. Allosteric receptor activation depends on conformational features of the autoantibody binding site. Elucidating these features...

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Detalles Bibliográficos
Autores principales: Wölfel, Angela, Sättele, Mathias, Zechmeister, Christina, Nikolaev, Viacheslav O., Lohse, Martin J., Boege, Fritz, Jahns, Roland, Boivin‐Jahns, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373925/
https://www.ncbi.nlm.nih.gov/pubmed/32436653
http://dx.doi.org/10.1002/ehf2.12747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373925/
https://www.ncbi.nlm.nih.gov/pubmed/32436653
http://dx.doi.org/10.1002/ehf2.12747

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