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Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1 kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by engaging intron-terminal splice sites...

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Detalles Bibliográficos
Autores principales: Parra, Marilyn, Zhang, Weiguo, Vu, Jonathan, DeWitt, Mark, Conboy, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373989/
https://www.ncbi.nlm.nih.gov/pubmed/32312846
http://dx.doi.org/10.1261/rna.075028.120