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Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1 kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by engaging intron-terminal splice sites...
Autores principales: | Parra, Marilyn, Zhang, Weiguo, Vu, Jonathan, DeWitt, Mark, Conboy, John G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373989/ https://www.ncbi.nlm.nih.gov/pubmed/32312846 http://dx.doi.org/10.1261/rna.075028.120 |
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