KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

BACKGROUND: Kaposi’s Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly inf...

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Detalles Bibliográficos
Autores principales: Gilardini Montani, Maria Saveria, Falcinelli, Luca, Santarelli, Roberta, Granato, Marisa, Romeo, Maria Anele, Cecere, Nives, Gonnella, Roberta, D’Orazi, Gabriella, Faggioni, Alberto, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374093/
https://www.ncbi.nlm.nih.gov/pubmed/32418990
http://dx.doi.org/10.1038/s41416-020-0872-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374093/
https://www.ncbi.nlm.nih.gov/pubmed/32418990
http://dx.doi.org/10.1038/s41416-020-0872-0

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