Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets

Development of small molecule compounds that target several cancer drivers has shown great therapeutic potential. Here, we developed a new generation of highly potent thienopyranone (TP)-based inhibitors for the BET bromodomains (BDs) of the transcriptional regulator BRD4 that have the ability to si...

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Detalles Bibliográficos
Autores principales: Vann, Kendra R., Pal, Dhananjaya, Morales, Guillermo A., Burgoyne, Adam M., Durden, Donald L., Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374098/
https://www.ncbi.nlm.nih.gov/pubmed/32694708
http://dx.doi.org/10.1038/s41598-020-68964-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374098/
https://www.ncbi.nlm.nih.gov/pubmed/32694708
http://dx.doi.org/10.1038/s41598-020-68964-6

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